Widefield imaging of rapid pan-cortical voltage dynamics with an indicator evolved for one-photon microscopy
  • Oct. 12, 2023
  • A genetically encoded voltage indicator, JEDI-1P enable wide brain imaging of fast neural activity.
Automating the high-throughput screening of protein-based optical indicators and actuators
ACS Biochemistry Abstract
  • Oct. 31, 2022
  • A review of protein engineering approaches to screen and optimize optical sensors and indicators for biological systems.
Sustained deep-tissue voltage recording using a fast indicator optimized for two-photon microscopy
Cell Abstract
  • Aug. 18, 2022
  • Engineer a fast, sensitive, bright and photostable genetically encoded voltage indicator called JEDI-2P that is compatible with two-photon microscopy. JEDI-2P enables deep-tissue optical recording of rapid voltage dynamics over tens of minutes.
🔗 Media coverage (BioArt (Chinese), Baylor College of Medicine News)

Versatile phenotype-activated cell sorting
Science Advances Figure 1
  • Oct. 23, 2020
  • A versatile high-throughput technique called SPOTlight to isolate individual yeast or human cells with unique spatiotemporal profiles from heterogeneous populations. This technique allows engineer of a bright and new yellow fluorescent protein mGold.

Pending patents:

  • Photostable fluorescent proteins (US20230203110A1)
  • Methods and compositions for retrieving cellular structures based on spatiotemporal profiles (US20230031708A1)
🔗 mGold (FPBase), Media coverage (Baylor College of Medicine Blog)